On August 21, 2007, he started taping for the fantasy series Zaido: Pulis Pangkalawakan with Aljur Abrenica and Marky Cielo.
The same year, Trillo joined the stellar cast of Magdusa Ka, an afternoon soap opera which later earned an International Emmy nomination the following year.
Late 2008 when he starred in the comic-based superhero series Gagambino, playing as the main character.
In 2010, he also began co-hosting the variety show, Party Pilipinas.
Midway through the series, GMA Network management announced that Trillo would be pulled out from the said show to once again star in another fantasy-themed television series Majika, in the end Trillo was allowed to complete Etheria.
He also starred in the horror-suspense film Pamahiin and was included in the network's noontime show SOP as a co-host where he also played drums as part of the show's "Starband".
remarks on saying "No one can replace Ogie as Boy Pick-up".He pursued a college education at Miriam College taking B. After transferring to GMA Network and becoming a contract star, he landed his first role for the network in the youth-oriented drama Kahit Kailan where he played a supporting character named David.He was also cast in several outings like Twin Hearts and Love to Love.Trillo visited ABS-CBN via his guesting in Kris TV to promote his 2015 movie You're Still The One alongside Maja Salvador, Ellen Adarna and Richard Yap under Regal Entertainment Inc. The same year, Trillo launched his first VIVA Films movie, Felix Manalo where he received a Movie Actor of the Year award from PMPC Star Awards for Movies.The show occupied the Friday night timeslot of the now-defunct musical variety show, Vilma! The cast of the show where: Aiko Melendez, and Eric Fructuoso, and newcomers Susan Lozada, Assunta De Rossi, Jackie De Guzman, Wendell Ramos and Antonio Aquitania (who were hired by the late GMA talent manager, Douglas Quijano) who is one of the first casts of Bubble Gang with Alcasid and Michael V. There were two extras in the show, such as Diego Llorico, who was working as a production assistant to the show, currently also a segment producer, & Susan Lozada's personal assistant Marissa "Mykah" Flores, she was eventually one of Wendell Ramos love interest.The following year, 2005, Trillo officially became a leading man when he was paired with Angel Locsin in the television adaptation of the iconic superhero Darna.He also starred in an afternoon family drama Now and Forever: Agos where he received a Best Drama Actor nomination from PMPC Star Awards for TV.Following this recognition, he received five more Best Actor trophies from the Film Academy of the Philippines, the Filipino Academy of Movie Arts and Sciences (FAMAS), the PMPC Star Awards for Movies, Golden Screen Awards and the Young Critics Circle.He was also included in the third installment of Mano Po.That same year, he reprised his role for Mulawin: The Movie, and appeared in the film Blue Moon.In 2005, in GMA Network fantasy series Encantadia, Trillo was cast as lead character in Etheria, where he portrayed the Sapirian prince, Raquim.